欧阳小琨(XK Ouyang)，教授，博士生导师，浙江海洋大学东海学者。现任浙江海洋大学药学系主任，食品与药学学院医用生物材料团队负责人。主持在研国家重点研发项目一项、主持完成国家基金面上项目2项，承担省部级科研项目10余项，以第一作者或通讯作者发表SCI期刊论文80余篇(其中ESI高被引论文8篇)，SCI总被引5400余次，H指数46，获授权发明专利50余项，以第一完成人获中国商业联合会科技进步奖一等奖2项、二等奖1项、三等奖2项，获中国轻工业联合会科技进步奖三等奖一项，舟山市科技进步奖二等奖一项，获浙江省科技进步奖一等奖一项(排名第五)、三等奖二项(分别排名第二和第三)，入选全球前2%顶尖科学家榜单(World's Top 2% Scientists 2020、2021、2022、2023)。
研究方向：1. 海洋生物资源功能化利用；2. 生物材料；3. 纳米药物。
Email: xkouyang @aomencai.net； [email protected]
主要学习工作经历
2004.07-2007.06，浙江大学，化学工程，博士
2007.07-至今，浙江海洋大学，历任讲师、副教授、教授
学术兼职
国家自然科学基金网络评审专家、浙江省、湖南省、山东省、河北省、广东省、河南省等省份(自然科学基金、科技计划)科技评审专家。Chemical Engineering Journal、Journal of Hazardous Materials、Carbohydrate Polymers、ACS Applied Materials & Interfaces、ACS Sustainable Chemistry & Engineering、ACS Applied Nano Materials、 ACS Omega、Chemosphere、International Journal of Biological Macromolecules、International Journal of Nanomedicine、Langmuir、Separation and Purification Technology等三十余个国际期刊的审稿专家，兼任东华理工大学学报（自然科学版）编委、Frontiers in materials(SCI)、Sustainability(SCI) 、SN Applied Sciences编委(特邀编委)。
获奖
2023，贻贝全产业链加工关键技术及系列产品开发与产业化，浙江省科技进步奖三等奖（3/7）
2017，海洋风味水产品中有害物质分析与质量控制关键技术研究, 中国轻工业联合会科技进步三等奖(1/6)
2016，海产品危害因子分析与质量控制关键技术构建与应用, 浙江省科技进步奖三等奖(2/6)
2016，水产品中手性药物残留检测技术体系构建与应用，中国商业联合会科技进步一等奖(1/5)
2015，海产品有害物质分析与质量控制关键技术研究, 中国商业联合会科技进步二等奖(1/8)
2009，雷公藤有效成分的提取分离及质量控制技术，浙江省科技进步奖一等奖(5/13)
代表性项目
1. 国家重点研发计划政府间国际科技创新合作项目，异质结功能化小球藻纳米胶囊调控肿瘤微环境与肿瘤光动力/免疫协同治疗研究、2023/04-2026/03、主持。
2. 国家自然科学基金面上项目，以功能离子液体微胶囊为介质分离雷公藤生物碱的应用基础研究、2010/01-2012/12，主持。
代表性论文 (*标记为通讯作者)
[23] Z Liu, JH Ling*, N Wang*, XK Ouyang*, Redox homeostasis disruptors enhanced cuproptosis effect for synergistic photothermal/chemodynamic therapy, Journal of Colloid and Interface Science, 2025, 678: 1060-1074. (IF 9.4).
[22]W Hu, LL Yang, HT Liang, DG Sun, XK Ouyang*, Nan Wang*, GC Yang*, Disulfiram-loaded CuO2 nanocarriers for enhanced synergistic chemodynamic/chemotherapy, Journal of Colloid and Interface Science, 2024, 674:9-18. (IF 9.4).
[21] SH Zhao, Junhong Ling*, Nan Wang*, XK Ouyang*, Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing, Chemical Engineering Journal, 2024, 497:154517. (IF 13.3)
[20] XH Wang, MY Ren, N Wang*, JH Ling, YH He, SY Huang, XK Ouyang*, Zeolitic imidazolate framework-8@polydopamine decorated carboxylated chitosan hydrogel with photocatalytic and photothermal antibacterial activity for infected wound healing, Journal of Colloid and Interface Science, 2024, 675:1040-1051. (IF 9.4).
[19]BJ Cheng, RL Wang, XH Wang, N Wang*, XK Ouyang*, Heterojunction functionalized sodium alginate/carboxylated cellulose nanocrystals film enhancing sterilization performance for wound healing, Carbohydrate Polymers, 2024, 345: 122550. (IF 10.7)
[18] Liang JH, Ling JH, Sun DG, Wu GH, XK Ouyang*, Wang N*, Yang GC*, Dextran-based antibacterial hydrogel dressings for accelerating infected wound healing by reducing inflammation levels, Advanced Healthcare Materials, 2024: 202400494. (IF 10)
[17] Zhu YF, Wang N, Ling JH, Yang LL, XK Ouyang*, Omer AM, Yang GC*. In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy, Journal of colloid and interface science, 2024, 660: 637-646. (IF 9.4)
[16] Liang JH, Ling JH, Zhang X, XK Ouyang*, Omer AM, Yang GC*. pH/glutathione dual-responsive copper sulfide-coated organic mesoporous silica for synergistic chemo-photothermal therapy, Journal of colloid and interface science, 2024, 657:1-14. (IF 9.4)
[15] Zhu YF, Ling JH, Xu XY, XK Ouyang*, Wang N*. Redox and pH dual sensitive carboxymethyl chitosan functionalized polydopamine nanoparticles loaded with doxorubicin for tumor chemo-photothermal therapy, International Journal of Biological Macromolecules, 2023, 240: 124488. (IF 8.025)
[14] Chen J, Zhao LJ, Ling JH, Yang LY, XK Ouyang*, A quaternized chitosan and carboxylated cellulose nanofiber-based sponge with a microchannel structure for rapid hemostasis and wound healing, International Journal of Biological Macromolecules, 2023, 233: 123631. (IF 8.025)
[13] Liu CN, Ling JH*, Yang LY, XK Ouyang*, Wang N*. Chitosan-based carbon nitride-polydopamine‑silver composite dressing with antibacterial properties for wound healing, Carbohydrate Polymers, 2023, 303: 120436. (IF 10.723)
[12] XK Ouyang*, Zhao LJ, Jiang FY, Ling JH*, Yang LY, Wang N*. Cellulose nanocrystal/calcium alginate-based porous microsphere for rapid hemostasis and wound healing. Carbohydrate Polymers, 2022, 293:119688. (IF 10.723 )
[11] Zhang X; Zhu YF; Fan LH; Ling JH*; Yang LY; Wang N*; XK Ouyang*. Delivery of curcumin by fucoidan-coated mesoporous silica nanoparticles: Fabrication, characterization, and in vitro release performance. International Journal of Biological Macromolecules, 2022, 211:368-379. (IF 8.025)
[10] Zhang H; Feng HZ; Ling JH; XK Ouyang*; Song XY*, Enhancing the stability of zein/fucoidan composite nanoparticles with calcium ions for quercetin delivery. International Journal of Biological Macromolecules, 2021, 193, 2070-2078. (IF 8.025)
[9] Zhang DC; Jiang FY; Ling JH; XK Ouyang*; Wang YG*, Delivery of curcumin using a zein-xanthan gum nanocomplex: Fabrication, characterization, and in vitro release properties. Colloids and Surfaces B-Biointerfaces, 2021, 204, 111827. (IF 5.999)
[8] Fan LH; Lu YQ; XK Ouyang*; Ling JH*, Development and characterization of soybean protein isolate and fucoidan nanoparticles for curcumin encapsulation. International Journal of Biological Macromolecules, 2021, 169, 194-205. (IF 8.025)
[7] Jiang FY; Yang L L; Wang SY; Ying XG; Ling J H; XK Ouyang*, Fabrication and characterization of zein-alginate oligosaccharide complex nanoparticles as delivery vehicles of curcumin. Journal of Molecular Liquids, 2021, 342, 116937. (IF 6.633)
[6] Zhang H; Yang LY; Tong MD; Lu Y; XK Ouyang*; Ling JH*, Encapsulation of curcumin using fucoidan stabilized zein nanoparticles: Preparation, characterization, and in vitro release performance. Journal of Molecular Liquids, 2021,329, 115586. (IF 6.633)
[5] Wang SY, Lu YQ, XK Ouyang*; Ling JH*, Fabrication of soy protein isolate/cellulose nanocrystal composite nanoparticles for curcumin delivery, International Journal of Biological Macromolecules, 2020, 165, 1468-1474. (IF 8.025)
[4] Sun XX, Pan CQ, Ying ZY, Yu DY, Duan XT, Huang FF, Ling JH*, XK Ouyang*, Stabilization of zein nanoparticles with k-carrageenan and tween 80 for encapsulation of curcumin, International Journal of Biological Macromolecules, 2020, 146:549-559. (IF 8.025)
[3] Lu YQ, Fan LH, Yang LY, Huang FF, XK Ouyang*, PEI-modified core-shell/bead-like amino silica enhanced poly (vinyl alcohol)/chitosan for diclofenac sodium efficient adsorption, Carbohydrate Polymers, 2020, 229:115459. (IF 10.723).
[2] Sun XX, Liu C, AM Omer*, Yang LY, XK Ouyang*, Dual-layered pH-sensitive alginate/chitosan/kappa-carrageenan microbeads for colon-targeted release of 5-fluorouracil, International Journal of Biological Macromolecules, 2019,132:487-494. (IF 8.025)
[1] Sun XX, Liu C, AM Ome(*), Lu W, Zhang S, Jiang X, Wu H, Yu D, XK Ouyang*, pH-sensitive ZnO/carboxymethyl cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil, International Journal of Biological Macromolecules, 2019,128:468-479. (IF 8.025)
代表性专利
(15) 张一鸣，欧阳小琨，梁建浩，一种用于组织创面修复的海绵复合物及其制备方法，授权发明专利：202210713997X
(14) 项昕晨，欧阳小琨，凌俊红，韩榕，范丽红,一种传递姜黄素的岩藻多糖-介孔二氧化硅复合纳米粒子，授权发明专利：2021111797050
(13) 骆君怡，欧阳小琨，章宏，一种递送姜黄素的大豆分离蛋白-卡拉胶纳米复合物，授权发明专利：2021 101085083
(12)黄莉莉, 欧阳小琨, 章宏, 一种共递送岩藻黄素和槲皮素的高粱醇溶蛋白-岩藻多糖复合物, 授权发明专利：2021101093126
(11) 韩榕，欧阳小琨，凌俊红，范丽红，一种递送岩藻黄素的褐藻寡糖-介孔二氧化硅纳米复合物，授权发明专利：202111179753X
(10) 欧阳小琨，赵丽娟，凌俊红，蒋方园，杨立业，一种基于海藻酸钠、纳晶纤维素的抗菌止血多孔微球，授权发明专利：2021 110610583
(9) 马瑞，欧阳小琨，王松艳，黄依如，一种递送姜黄素的zein-AOS复合纳米颗粒及其制备方法，授权发明专利：2021 107545288
(8) 叶文鹏，欧阳小琨，王南，赵丽娟，凌俊红，一种用于组织创伤愈合修复的纤维素壳聚糖单宁酸铜复合凝胶海绵及其制备方法, 授权发明专利：ZL2021113761744
(7) 韩榕，欧阳小琨，黄依如，范丽红，一种褐藻寡糖修饰的氨基化介孔二氧化硅纳米颗粒,授权发明专利：ZL202111060301X
(6)欧阳小琨，梁建浩，凌俊红，卢雨清，杨立业，一种阿霉素偶联壳寡糖的纳米粒子， 授权发明专利：ZL2021110898603
(5)欧阳小琨，卢雨清，杨立业，范丽红，一种利用南极磷虾壳制备氨基壳聚糖的方法，授权发明专利：ZL2019109600259
(4)欧阳小琨，卢雨清，杨立业，范丽红，一种南极磷虾小分子肽的制备方法，授权发明专利：ZL 2019108714623
(3)欧阳小琨，卢雨清，杨立业，范丽红，一种基于南极磷虾壳的止血材料的制备方法及其应用，授权发明专利：ZL 2019109600329
(2) 欧阳小琨，杨立业，郁迪，一种吸附南极磷虾油中砷的方法，授权发明专利，ZL 2017108133999
(1) 欧阳小琨，马剑茵，一种传递5-氟尿嘧啶微球的制备方法，授权发明专利，ZL 201710859517X
